In this case, by describing the curves with straight lines, the slopes are different and equal to 153. Properties and applications of microemulsions matyjaszewski. Microemulsions potential carrier for improved drug delivery. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Right part from boundary line in phase diagram shows us the region in which self microemulsifying region exists. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution.
Formulation, characterization, and clinical evaluation of. Jul 02, 2011 a microemulsion gel formulation comprising of isopropyl myristate, tween 80, nbutanol, and water was deemed promising as a successful topical delivery system of ctm for the treatment of skin fungal infections. It was characterized for globule size and physical stability. Doylea nanoemulsions are kinetically stable liquidinliquid dispersions with droplet sizes on the order of 100 nm. Formulation and evaluation of microemulsionbased hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Pdf formulation and evaluation of microemulsionbased. The purpose of this study was to develop microemulsion based hydrogel formulation for topical delivery of bifonazole with an objective. The advantages of this solid microemulsion precondoi 10. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting.
Quality by design qbd approach for optimization of. Delivery of gatifloxacin using microemulsion as vehicle. Deviations from the actual formulation may cause the breaking of the microemulsion and formation of an unstable macroemulsion. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Permeation experiments on the microemulsion ingel showed a better performance of the analog formulated at 0. Luliconazole microemulsion was prepared by varying the concentration of surfactants while the oil concentration was kept fixed. Koli 146 in the present study, non ionic surfactants namely tween20, tween 80, labrasol, peceol and plurol oleique were screened as nonionic surfactants are less toxic than ionic surfactants.
Formulation and evaluation of microemulsionbased hydrogel. The influence of composition, and added salts and polyols on the stability of an oilinwater microemulsion formulation and on the apparent pk a apk a of the used oleate surfactant is investigated high temperature favours a decrease of the apk a and leads to the formation of more hydrated micelles. Microemulsion and its mechanism of formation this video gives an explanation of microemulsion and its mechanism of formation. A recognized and classical approach to microemulsion formulation is to utilize phase diagrams. Formulation development, in vitro and in vivo evaluation of. With all types of microemulsions, wateroilwater type microemulsion offers unique advantages, including these.
The purpose of this study was to develop microemulsionbased hydrogel formulation for topical delivery of bifonazole with an objective. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Development and evaluation of a microemulsion formulation for. Many of these drugs are good candidates for formulation into.
An me gel base composed of 35% ipm, 20% water, and 45% tween 80. Preparation and characterization of oilinwater and water. For other materials, the microemulsion contains all above. In chapter 1 a short introduction about the background, various aspects. Development of clinical dosage forms for a poorly watera. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. Three distinct microemulsions oil external, water external and middle phase can be used for drug delivery, depending upon the type of drug. Preparation and evaluation of microemulsion systems. Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. Formulation and structural study of a biocompatible waterinoil microemulsion as an appropriate enzyme carrier. In the most microemulsion phases, the surfactant is. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Pdf formulation of nimesulide microemulsion based hydrogel. Water and oil can be made completely miscible by adding a sufficient amount of an amphiphilic compound, such as soap or a detergent.
The aim of this study was to develop a microemulsion me formulation containing an association of itraconazole itc and clotrimazole clt as a transdermal delivery system for the treatment of. Microemulsion me formulation how to develop a microemulsion me formulation microemulsion are, by definition, optically clear dispersion of one physically incompatible liquid into another. Formulation and development of microemulsion and smedds akshay r. The purpose of this study was to develop microemulsion based hydrogel formulation for topical delivery of bifonazole with an objective to increase the solubility and skin permeability of the drug. Quantification in pharmaceutical opthalmic microemulsion formulation by rphplc pratikeshkumar patel1, priti patel2 and prabhanjan giram1 1polymer science and engineering, csir ncl, pune, maharashtra, india 2sayajirao university of baroda, gujarat, india ho ho o o ho figure 1. The most promising surfactants are those which provide thermally phase stable microemulsions. Formulation and structural study of a biocompatible water. These results highlight the potential of the designed matrices as delayed drug delivery systems along with the use of lower drug doses leading to reduced side effects. Microemulgel was prepared and characterized for drug content, viscosity, spreadability, in vitro permeation study, skin irritation test, in vitro antifungal. Formulation and characterization of a novel solid microemulsion preconcentrate system for oral delivery of a poorly watersoluble drug ping li, 1sara r. Tween 80 was used as surfactant in the formulation of gatifloxacin microemulsion as it helped in the corneal permeation of parabens and it was found non toxic and nonirritating to the eyes lee et al. A surfactant formulation is injected into the reservoir in the surfactant. Microemulsion and its mechanism of formation youtube. Design and formulation of optimized microemulsions for dermal.
Development and evaluation of a microemulsion formulation. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have a droplet size less than 100 nm. Neoral is formulated with a finer dispersion, giving it a more rapid and predictable absorption and less inter and intra patient variability 52. For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. Pdf preparation and evaluation of microemulsion containing. Thus, in this research, we tried to design the novel ow microemulsion formulation of glimepiride which improve the gastrointestinal absorption by raising its water. Design and formulation of optimized microemulsions for. The surfactants stimulate the formation of a microemulsion in the porous reservoir between reservoir brine and crude oil, which reduces the interfacial tension between the two. Preparation and characterization of oilinwater and waterin.
In the most microemulsion phases, the surfactant is highly soluble in both liquid phases. Microemulsions may be used as the carrier for protein and peptide delivery to the gi tract. In addition, an explanation of the use of ternary phase diagrams is included to assist the formulator. Degradation of proteins is effectively reduced due to the use of relatively mild conditions during the formulation process of microemulsions. Formulation and stability of a soap microemulsion and the. Microemulsion microemulsions are monodispersed spherical droplets diameter pdf available in international journal of pharmaceutical investigation 23. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. Formulation and evaluation of microemulsion based topical. Microemulsion formulations have also been suggested to alter the polar pathways. Formulation and development of microemulsion and smedds.
The oil phase studied included lemon oil, oleic acid, benzyl alcohol, or isopropyl myristate. The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome transfersome and microemulsion formulations as potential topical delivery systems for meloxicam. An olive oil based microemulsion formulation with tween 80 as surfactant and peg 400 as cosurfactant was developed for oral delivery of famotidine. Formulation and evaluation of microemulsion based delivery. Oleic acid was screened as the oil phase of microemulsions.
Also described are typical surfactants and solvents that can be used in this formulation work. Formulation development, in vitro and in vivo evaluation. The composition of the different formulated microemulsion batches a1a3 is shown in table 2. Nanoemulsion and nanoemulgel as a topical formulation. Dec 28, 2015 microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Nimesulide has extensively used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old and in the treatment of rheumatoid arthritis and inflammatory conditions. Formulation of microemulsion lornoxicam 1% ww was dissolved in oily phase consisting of equal amount of camphor and menthol. Original article formulation and evaluation of microemulsion. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have. Materials following were the kind gift samples provided by companies. Pg as surfactantcosurfactant mixture scos in ratio of 15. At technical con centrations approaching 30%ww, the formulation cost of a microemulsion approximates that of an emulsifiable concentrate assuming 1. The aim of this study was to develop a microemulsion me formulation containing an. For example, employing higher temperature and including an additional salt in a microemulsion.
The final product developed is a lyophilized amphotericin b, oil and surfactant blend for reconstitution in water to yield a microemulsion containing 5 mgml of the. Microemulsion existence region was determined using the pseudoternary phase diagrams for preparing different formulations. This paper describes the preparation and assessment. These microemulsion systems are finding utility in a range of applications, including consumer and industrial cleaning formulations, chemical reaction media. The composition of the prepared systems is presented in table i. Microemulsions for oral administration and their therapeutic. The role of surfactant in the formulation of microemulsion is to lower the interfacial tension which will ultimately facilitates dispersion process during the preparation. Finally, optimized formulation was compared with the marketed product.
Microemulsion formulation is transparent, thermodynamically stable and a liquid mixture of oil, surfactants, cosurfactant and an aqueous phase. The resultant microemulsion is studied by observing the physical appearance of the formulation as a function of time and temperature usually upon standing at 30c for 30 minutes. For microemulsions, particle size, electrical conductivity and viscosity studies were performed. Oct 01, 20 for example, the microemulsion forms at 41 c, 54 c and 75 c for 0. Microemulsion dosage forms for oral or parenteral use based on nonionic. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. For microemulsions, particle size, electrical conductivity and viscosity. The aim of the present study was to design novel drug delivery system containing ramipril microemulsion. For historical reasons, such stable homogeneous solutions are called microemulsions.
The free energy of microemulsion formation can be considered. The lornoxicam solution was then mixed with mixture of surfactant and cosurfactant. The aim of this study was to develop a microemulsion me formulation containing an association of itraconazole. Formulation of microemulsion from all fivephase diagrams, the ratio of 2. A microemulsion formulation of cyclosporine, named neoral has been introduced to replace sandimmune, a crude oilinwater emulsion of cyclosporine formulation. Surfactants the role of surfactant in the formulation of microemulsion is to lower the interfacial tension which will ultimately facilitates dispersion process during the preparation of microemulsion and provide a flexible. Finally, an appropriate amount of water was added to the lornoxicam solution mixture drop by drop to get. Several authors have reported preparation of microemulsions using alcohols of short or medium. Microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Pdf formulation and evaluation of microemulsionbased hydrogel. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation. In this study, microemulsionbased hydrogel formulation containing bifonazole was prepared using hpmc k100m as gelling agent. Microemulsions may be defined as oil dispersed in water or water dispersed in oil. Bifonazole is a broad spectrum azole antifungal agent, which is effective against yeasts, moulds, dermatophytes, and other fungi and it is used to treat skin infections such as tinea, athletes foot tinea pedis, and.
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